ANIKA THERAPEUTICS INC

Ticker: ANIK CUSIP: 035255108 Class: COM

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 297,979 Value ($000) $2,864 Avg Close $9.58 Range $8.67 - $10.75

Q3 2025

Shares 175,315 Value ($000) $1,648 Avg Close $9.55 Range $7.87 - $11.84

Q2 2025

Shares 124,079 Value ($000) $1,313 Avg Close $12.62 Range $10.47 - $15.45

Q1 2025

Shares 167,760 Value ($000) $2,521 Avg Close $16.64 Range $14.79 - $18.37

Q4 2024

Shares 153,764 Value ($000) $2,531 Avg Close $19.72 Range $15.83 - $25.65

Q3 2024

Shares 154,061 Value ($000) $3,805 Avg Close $25.93 Range $24.15 - $29.12

Q2 2024

Shares 152,923 Value ($000) $3,874 Avg Close $25.92 Range $23.92 - $28.67

Q1 2024

Shares 153,489 Value ($000) $3,899 Avg Close $24.20 Range $21.00 - $27.31

Q4 2023

Shares 169,244 Value ($000) $3,835 Avg Close $20.69 Range $17.88 - $24.25

Q3 2023

Shares 192,065 Value ($000) $3,578 Avg Close $20.74 Range $16.54 - $26.32

Q2 2023

Shares 143,677 Value ($000) $3,733 Avg Close $26.76 Range $24.49 - $29.26

Q1 2023

Shares 138,267 Value ($000) $3,971 Avg Close $29.76 Range $23.02 - $32.33

Q4 2022

Shares 145,626 Value ($000) $4,311 Avg Close $28.44 Range $23.19 - $32.51

Q3 2022

Shares 152,028 Value ($000) $3,618 Avg Close $23.01 Range $21.44 - $25.21

Q2 2022

Shares 192,760 Value ($000) $4,302 Avg Close $22.31 Range $19.95 - $25.67

Q1 2022

Shares 170,389 Value ($000) $4,278 Avg Close $30.49 Range $24.21 - $36.85

Q4 2021

Shares 161,675 Value ($000) $5,793 Avg Close $40.03 Range $35.65 - $45.81

Q3 2021

Shares 177,882 Value ($000) $7,571 Avg Close $41.19 Range $38.52 - $44.87

Q2 2021

Shares 192,816 Value ($000) $8,347 Avg Close $42.59 Range $38.88 - $48.37

Q1 2021

Shares 192,373 Value ($000) $7,847 Avg Close $37.93 Range $32.30 - $47.15

Q4 2020

Shares 156,895 Value ($000) $7,101 Avg Close $37.95 Range $32.04 - $47.48

Q3 2020

Shares 167,429 Value ($000) $5,925 Avg Close $36.12 Range $32.21 - $39.70

Q2 2020

Shares 177,346 Value ($000) $6,691 Avg Close $32.95 Range $27.38 - $38.17

Q1 2020

Shares 237,255 Value ($000) $6,859 Avg Close $40.45 Range $22.01 - $55.10

Q4 2019

Shares 320,382 Value ($000) $16,612 Avg Close $58.09 Range $51.37 - $75.72

Q3 2019

Shares 408,294 Value ($000) $22,411 Avg Close $51.34 Range $39.45 - $58.93

Q2 2019

Shares 413,051 Value ($000) $16,778 Avg Close $36.46 Range $29.98 - $41.88

Q1 2019

Shares 311,608 Value ($000) $9,423 Avg Close $34.25 Range $29.01 - $40.71

Q4 2018

Shares 161,493 Value ($000) $5,427 Avg Close $36.09 Range $29.58 - $43.45

Q3 2018

Shares 162,095 Value ($000) $6,837 Avg Close $39.51 Range $31.91 - $44.95

Q2 2018

Shares 91,162 Value ($000) $2,917 Avg Close $41.18 Range $28.54 - $49.75

Q1 2018

Shares 108,083 Value ($000) $5,374 Avg Close $56.50 Range $45.74 - $69.81

Q4 2017

Shares 127,187 Value ($000) $6,857 Avg Close $55.35 Range $51.10 - $60.29

Q3 2017

Shares 129,534 Value ($000) $7,513 Avg Close $52.27 Range $45.09 - $59.28

Q2 2017

Shares 114,453 Value ($000) $5,647 Avg Close $46.05 Range $42.51 - $49.99

Q1 2017

Shares 78,629 Value ($000) $3,416 Avg Close $47.74 Range $41.64 - $52.39

Q4 2016

Shares 85,264 Value ($000) $4,175 Avg Close $46.23 Range $41.38 - $50.19

Q3 2016

Shares 58,310 Value ($000) $2,790 Avg Close $49.40 Range $45.25 - $54.96

Q2 2016

Shares 32,043 Value ($000) $1,719 Avg Close $47.12 Range $42.36 - $53.68

Q1 2016

Shares 31,344 Value ($000) $1,402 Avg Close $40.56 Range $35.07 - $47.24

Q1 2015

Shares 5,112 Value ($000) $210 Avg Close $40.43 Range $37.05 - $45.35

Q1 2014

Shares 6,196 Value ($000) $255 Avg Close $37.17 Range $28.79 - $52.49

Q4 2013

Shares 5,731 Value ($000) $219 Avg Close $30.85 Range $23.26 - $38.68

Q3 2013

Shares 39,224 Value ($000) $940 Avg Close $22.45 Range $17.02 - $27.80

Q2 2013

Shares 17,472 Value ($000) $297 Avg Close $14.42 Range $12.26 - $18.07

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	297,979	$2,864	$9.58	$8.67 - $10.75
Q3 2025	175,315	$1,648	$9.55	$7.87 - $11.84
Q2 2025	124,079	$1,313	$12.62	$10.47 - $15.45
Q1 2025	167,760	$2,521	$16.64	$14.79 - $18.37
Q4 2024	153,764	$2,531	$19.72	$15.83 - $25.65
Q3 2024	154,061	$3,805	$25.93	$24.15 - $29.12
Q2 2024	152,923	$3,874	$25.92	$23.92 - $28.67
Q1 2024	153,489	$3,899	$24.20	$21.00 - $27.31
Q4 2023	169,244	$3,835	$20.69	$17.88 - $24.25
Q3 2023	192,065	$3,578	$20.74	$16.54 - $26.32
Q2 2023	143,677	$3,733	$26.76	$24.49 - $29.26
Q1 2023	138,267	$3,971	$29.76	$23.02 - $32.33
Q4 2022	145,626	$4,311	$28.44	$23.19 - $32.51
Q3 2022	152,028	$3,618	$23.01	$21.44 - $25.21
Q2 2022	192,760	$4,302	$22.31	$19.95 - $25.67
Q1 2022	170,389	$4,278	$30.49	$24.21 - $36.85
Q4 2021	161,675	$5,793	$40.03	$35.65 - $45.81
Q3 2021	177,882	$7,571	$41.19	$38.52 - $44.87
Q2 2021	192,816	$8,347	$42.59	$38.88 - $48.37
Q1 2021	192,373	$7,847	$37.93	$32.30 - $47.15
Q4 2020	156,895	$7,101	$37.95	$32.04 - $47.48
Q3 2020	167,429	$5,925	$36.12	$32.21 - $39.70
Q2 2020	177,346	$6,691	$32.95	$27.38 - $38.17
Q1 2020	237,255	$6,859	$40.45	$22.01 - $55.10
Q4 2019	320,382	$16,612	$58.09	$51.37 - $75.72
Q3 2019	408,294	$22,411	$51.34	$39.45 - $58.93
Q2 2019	413,051	$16,778	$36.46	$29.98 - $41.88
Q1 2019	311,608	$9,423	$34.25	$29.01 - $40.71
Q4 2018	161,493	$5,427	$36.09	$29.58 - $43.45
Q3 2018	162,095	$6,837	$39.51	$31.91 - $44.95
Q2 2018	91,162	$2,917	$41.18	$28.54 - $49.75
Q1 2018	108,083	$5,374	$56.50	$45.74 - $69.81
Q4 2017	127,187	$6,857	$55.35	$51.10 - $60.29
Q3 2017	129,534	$7,513	$52.27	$45.09 - $59.28
Q2 2017	114,453	$5,647	$46.05	$42.51 - $49.99
Q1 2017	78,629	$3,416	$47.74	$41.64 - $52.39
Q4 2016	85,264	$4,175	$46.23	$41.38 - $50.19
Q3 2016	58,310	$2,790	$49.40	$45.25 - $54.96
Q2 2016	32,043	$1,719	$47.12	$42.36 - $53.68
Q1 2016	31,344	$1,402	$40.56	$35.07 - $47.24
Q1 2015	5,112	$210	$40.43	$37.05 - $45.35
Q1 2014	6,196	$255	$37.17	$28.79 - $52.49
Q4 2013	5,731	$219	$30.85	$23.26 - $38.68
Q3 2013	39,224	$940	$22.45	$17.02 - $27.80
Q2 2013	17,472	$297	$14.42	$12.26 - $18.07