ANIKA THERAPEUTICS INC

Ticker: ANIK CUSIP: 035255108 Class: COM

FIRST CITIZENS BANK & TRUST CO's Holding History (CIK: 0001092203)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 4,999 Value ($000) $245 Avg Close $46.23 Range $41.38 - $50.19

Q3 2016

Shares 7,249 Value ($000) $347 Avg Close $49.40 Range $45.25 - $54.96

Q2 2016

Shares 12,886 Value ($000) $691 Avg Close $47.12 Range $42.36 - $53.68

Q1 2016

Shares 14,132 Value ($000) $632 Avg Close $40.56 Range $35.07 - $47.24

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	4,999	$245	$46.23	$41.38 - $50.19
Q3 2016	7,249	$347	$49.40	$45.25 - $54.96
Q2 2016	12,886	$691	$47.12	$42.36 - $53.68
Q1 2016	14,132	$632	$40.56	$35.07 - $47.24