ANIKA THERAPEUTICS INC

Ticker: ANIK CUSIP: 035255108 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 233,808 Value ($000) $2,247 Avg Close $9.58 Range $8.67 - $10.75

Q3 2025

Shares 79,921 Value ($000) $751 Avg Close $9.55 Range $7.87 - $11.84

Q4 2024

Shares 12,096 Value ($000) $199 Avg Close $19.72 Range $15.83 - $25.65

Q3 2024

Shares 21,336 Value ($000) $527 Avg Close $25.93 Range $24.15 - $29.12

Q2 2024

Shares 28,100 Value ($000) $712 Avg Close $25.92 Range $23.92 - $28.67

Q1 2024

Shares 47,270 Value ($000) $1,201 Avg Close $24.20 Range $21.00 - $27.31

Q4 2023

Shares 60,264 Value ($000) $1,366 Avg Close $20.69 Range $17.88 - $24.25

Q3 2023

Shares 17,614 Value ($000) $328 Avg Close $20.74 Range $16.54 - $26.32

Q2 2023

Shares 64,550 Value ($000) $1,677 Avg Close $26.76 Range $24.49 - $29.26

Q1 2023

Shares 48,405 Value ($000) $1,390 Avg Close $29.76 Range $23.02 - $32.33

Q4 2022

Shares 62,632 Value ($000) $1,854 Avg Close $28.44 Range $23.19 - $32.51

Q3 2022

Shares 32,753 Value ($000) $780 Avg Close $23.01 Range $21.44 - $25.21

Q2 2022

Shares 65,366 Value ($000) $1,459 Avg Close $22.31 Range $19.95 - $25.67

Q1 2022

Shares 48,277 Value ($000) $1,212 Avg Close $30.49 Range $24.21 - $36.85

Q4 2021

Shares 53,655 Value ($000) $1,922 Avg Close $40.03 Range $35.65 - $45.81

Q3 2021

Shares 65,568 Value ($000) $2,791 Avg Close $41.19 Range $38.52 - $44.87

Q2 2021

Shares 115,925 Value ($000) $5,018 Avg Close $42.59 Range $38.88 - $48.37

Q1 2021

Shares 112,783 Value ($000) $4,600 Avg Close $37.93 Range $32.30 - $47.15

Q4 2020

Shares 52,234 Value ($000) $2,364 Avg Close $37.95 Range $32.04 - $47.48

Q3 2020

Shares 45,152 Value ($000) $1,598 Avg Close $36.12 Range $32.21 - $39.70

Q2 2020

Shares 27,534 Value ($000) $1,039 Avg Close $32.95 Range $27.38 - $38.17

Q1 2020

Shares 28,082 Value ($000) $812 Avg Close $40.45 Range $22.01 - $55.10

Q4 2019

Shares 5,375 Value ($000) $279 Avg Close $58.09 Range $51.37 - $75.72

Q3 2019

Shares 43,623 Value ($000) $2,394 Avg Close $51.34 Range $39.45 - $58.93

Q2 2019

Shares 163,505 Value ($000) $6,642 Avg Close $36.46 Range $29.98 - $41.88

Q1 2019

Shares 178,609 Value ($000) $5,401 Avg Close $34.25 Range $29.01 - $40.71

Q4 2018

Shares 144,032 Value ($000) $4,841 Avg Close $36.09 Range $29.58 - $43.45

Q3 2018

Shares 159,302 Value ($000) $6,719 Avg Close $39.51 Range $31.91 - $44.95

Q2 2018

Shares 116,852 Value ($000) $3,739 Avg Close $41.18 Range $28.54 - $49.75

Q1 2018

Shares 18,493 Value ($000) $919 Avg Close $56.50 Range $45.74 - $69.81

Q3 2017

Shares 11,697 Value ($000) $678 Avg Close $52.27 Range $45.09 - $59.28

Q2 2017

Shares 68,556 Value ($000) $3,383 Avg Close $46.05 Range $42.51 - $49.99

Q1 2017

Shares 35,532 Value ($000) $1,544 Avg Close $47.74 Range $41.64 - $52.39

Q4 2016

Shares 54,121 Value ($000) $2,650 Avg Close $46.23 Range $41.38 - $50.19

Q3 2016

Shares 33,045 Value ($000) $1,581 Avg Close $49.40 Range $45.25 - $54.96

Q2 2016

Shares 105,993 Value ($000) $5,687 Avg Close $47.12 Range $42.36 - $53.68

Q1 2016

Shares 152,145 Value ($000) $6,804 Avg Close $40.56 Range $35.07 - $47.24

Q4 2015

Shares 106,104 Value ($000) $4,049 Avg Close $38.25 Range $30.94 - $43.82

Q3 2015

Shares 51,264 Value ($000) $1,632 Avg Close $34.87 Range $30.93 - $39.24

Q2 2015

Shares 11,000 Value ($000) $363 Avg Close $35.67 Range $31.36 - $41.30

Q3 2014

Shares 6,795 Value ($000) $249 Avg Close $43.21 Range $35.39 - $50.89

Q2 2014

Shares 16,912 Value ($000) $784 Avg Close $44.47 Range $35.62 - $51.40

Q4 2013

Shares 5,300 Value ($000) $202 Avg Close $30.85 Range $23.26 - $38.68

Q3 2013

Shares 106,194 Value ($000) $2,545 Avg Close $22.45 Range $17.02 - $27.80

Q2 2013

Shares 52,918 Value ($000) $900 Avg Close $14.42 Range $12.26 - $18.07

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	233,808	$2,247	$9.58	$8.67 - $10.75
Q3 2025	79,921	$751	$9.55	$7.87 - $11.84
Q4 2024	12,096	$199	$19.72	$15.83 - $25.65
Q3 2024	21,336	$527	$25.93	$24.15 - $29.12
Q2 2024	28,100	$712	$25.92	$23.92 - $28.67
Q1 2024	47,270	$1,201	$24.20	$21.00 - $27.31
Q4 2023	60,264	$1,366	$20.69	$17.88 - $24.25
Q3 2023	17,614	$328	$20.74	$16.54 - $26.32
Q2 2023	64,550	$1,677	$26.76	$24.49 - $29.26
Q1 2023	48,405	$1,390	$29.76	$23.02 - $32.33
Q4 2022	62,632	$1,854	$28.44	$23.19 - $32.51
Q3 2022	32,753	$780	$23.01	$21.44 - $25.21
Q2 2022	65,366	$1,459	$22.31	$19.95 - $25.67
Q1 2022	48,277	$1,212	$30.49	$24.21 - $36.85
Q4 2021	53,655	$1,922	$40.03	$35.65 - $45.81
Q3 2021	65,568	$2,791	$41.19	$38.52 - $44.87
Q2 2021	115,925	$5,018	$42.59	$38.88 - $48.37
Q1 2021	112,783	$4,600	$37.93	$32.30 - $47.15
Q4 2020	52,234	$2,364	$37.95	$32.04 - $47.48
Q3 2020	45,152	$1,598	$36.12	$32.21 - $39.70
Q2 2020	27,534	$1,039	$32.95	$27.38 - $38.17
Q1 2020	28,082	$812	$40.45	$22.01 - $55.10
Q4 2019	5,375	$279	$58.09	$51.37 - $75.72
Q3 2019	43,623	$2,394	$51.34	$39.45 - $58.93
Q2 2019	163,505	$6,642	$36.46	$29.98 - $41.88
Q1 2019	178,609	$5,401	$34.25	$29.01 - $40.71
Q4 2018	144,032	$4,841	$36.09	$29.58 - $43.45
Q3 2018	159,302	$6,719	$39.51	$31.91 - $44.95
Q2 2018	116,852	$3,739	$41.18	$28.54 - $49.75
Q1 2018	18,493	$919	$56.50	$45.74 - $69.81
Q3 2017	11,697	$678	$52.27	$45.09 - $59.28
Q2 2017	68,556	$3,383	$46.05	$42.51 - $49.99
Q1 2017	35,532	$1,544	$47.74	$41.64 - $52.39
Q4 2016	54,121	$2,650	$46.23	$41.38 - $50.19
Q3 2016	33,045	$1,581	$49.40	$45.25 - $54.96
Q2 2016	105,993	$5,687	$47.12	$42.36 - $53.68
Q1 2016	152,145	$6,804	$40.56	$35.07 - $47.24
Q4 2015	106,104	$4,049	$38.25	$30.94 - $43.82
Q3 2015	51,264	$1,632	$34.87	$30.93 - $39.24
Q2 2015	11,000	$363	$35.67	$31.36 - $41.30
Q3 2014	6,795	$249	$43.21	$35.39 - $50.89
Q2 2014	16,912	$784	$44.47	$35.62 - $51.40
Q4 2013	5,300	$202	$30.85	$23.26 - $38.68
Q3 2013	106,194	$2,545	$22.45	$17.02 - $27.80
Q2 2013	52,918	$900	$14.42	$12.26 - $18.07