ANIKA THERAPEUTICS INC

Ticker: ANIK CUSIP: 035255108 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 126,483 Value ($000) $1,216 Avg Close $9.58 Range $8.67 - $10.75

Q3 2025

Shares 36,883 Value ($000) $347 Avg Close $9.55 Range $7.87 - $11.84

Q2 2025

Shares 19,083 Value ($000) $202 Avg Close $12.62 Range $10.47 - $15.45

Q1 2025

Shares 20,783 Value ($000) $312 Avg Close $16.64 Range $14.79 - $18.37

Q4 2024

Shares 26,283 Value ($000) $433 Avg Close $19.72 Range $15.83 - $25.65

Q3 2024

Shares 39,083 Value ($000) $965 Avg Close $25.93 Range $24.15 - $29.12

Q2 2024

Shares 52,383 Value ($000) $1,327 Avg Close $25.92 Range $23.92 - $28.67

Q1 2024

Shares 71,583 Value ($000) $1,818 Avg Close $24.20 Range $21.00 - $27.31

Q4 2023

Shares 62,283 Value ($000) $1,411 Avg Close $20.69 Range $17.88 - $24.25

Q3 2023

Shares 45,483 Value ($000) $847 Avg Close $20.74 Range $16.54 - $26.32

Q2 2023

Shares 70,683 Value ($000) $1,836 Avg Close $26.76 Range $24.49 - $29.26

Q1 2023

Shares 73,483 Value ($000) $2,110 Avg Close $29.76 Range $23.02 - $32.33

Q4 2022

Shares 86,283 Value ($000) $2,554 Avg Close $28.44 Range $23.19 - $32.51

Q3 2022

Shares 69,283 Value ($000) $1,649 Avg Close $23.01 Range $21.44 - $25.21

Q2 2022

Shares 84,883 Value ($000) $1,895 Avg Close $22.31 Range $19.95 - $25.67

Q1 2022

Shares 68,683 Value ($000) $1,725 Avg Close $30.49 Range $24.21 - $36.85

Q4 2021

Shares 59,583 Value ($000) $2,135 Avg Close $40.03 Range $35.65 - $45.81

Q3 2021

Shares 63,783 Value ($000) $2,715 Avg Close $41.19 Range $38.52 - $44.87

Q2 2021

Shares 107,783 Value ($000) $4,666 Avg Close $42.59 Range $38.88 - $48.37

Q1 2021

Shares 106,783 Value ($000) $4,356 Avg Close $37.93 Range $32.30 - $47.15

Q4 2020

Shares 82,783 Value ($000) $3,747 Avg Close $37.95 Range $32.04 - $47.48

Q3 2020

Shares 88,683 Value ($000) $3,138 Avg Close $36.12 Range $32.21 - $39.70

Q2 2020

Shares 92,193 Value ($000) $3,478 Avg Close $32.95 Range $27.38 - $38.17

Q1 2020

Shares 91,719 Value ($000) $2,652 Avg Close $40.45 Range $22.01 - $55.10

Q4 2019

Shares 115,619 Value ($000) $5,995 Avg Close $58.09 Range $51.37 - $75.72

Q3 2019

Shares 159,019 Value ($000) $8,729 Avg Close $51.34 Range $39.45 - $58.93

Q2 2019

Shares 202,419 Value ($000) $8,222 Avg Close $36.46 Range $29.98 - $41.88

Q1 2019

Shares 217,119 Value ($000) $6,566 Avg Close $34.25 Range $29.01 - $40.71

Q4 2018

Shares 125,419 Value ($000) $4,215 Avg Close $36.09 Range $29.58 - $43.45

Q3 2018

Shares 129,019 Value ($000) $5,442 Avg Close $39.51 Range $31.91 - $44.95

Q2 2018

Shares 143,519 Value ($000) $4,593 Avg Close $41.18 Range $28.54 - $49.75

Q1 2018

Shares 65,119 Value ($000) $3,238 Avg Close $56.50 Range $45.74 - $69.81

Q4 2017

Shares 65,519 Value ($000) $3,532 Avg Close $55.35 Range $51.10 - $60.29

Q3 2017

Shares 81,119 Value ($000) $4,705 Avg Close $52.27 Range $45.09 - $59.28

Q2 2017

Shares 91,719 Value ($000) $4,525 Avg Close $46.05 Range $42.51 - $49.99

Q1 2017

Shares 71,519 Value ($000) $3,107 Avg Close $47.74 Range $41.64 - $52.39

Q4 2016

Shares 66,111 Value ($000) $3,237 Avg Close $46.23 Range $41.38 - $50.19

Q3 2016

Shares 67,082 Value ($000) $3,210 Avg Close $49.40 Range $45.25 - $54.96

Q2 2016

Shares 87,983 Value ($000) $4,720 Avg Close $47.12 Range $42.36 - $53.68

Q1 2016

Shares 92,383 Value ($000) $4,131 Avg Close $40.56 Range $35.07 - $47.24

Q4 2015

Shares 76,183 Value ($000) $2,907 Avg Close $38.25 Range $30.94 - $43.82

Q3 2015

Shares 44,783 Value ($000) $1,432 Avg Close $34.87 Range $30.93 - $39.24

Q4 2014

Shares 8,683 Value ($000) $354 Avg Close $39.09 Range $34.16 - $43.24

Q3 2014

Shares 28,983 Value ($000) $1,063 Avg Close $43.21 Range $35.39 - $50.89

Q2 2014

Shares 57,383 Value ($000) $2,659 Avg Close $44.47 Range $35.62 - $51.40

Q1 2014

Shares 53,583 Value ($000) $2,203 Avg Close $37.17 Range $28.79 - $52.49

Q4 2013

Shares 64,083 Value ($000) $2,446 Avg Close $30.85 Range $23.26 - $38.68

Q3 2013

Shares 69,783 Value ($000) $1,672 Avg Close $22.45 Range $17.02 - $27.80

Q2 2013

Shares 40,883 Value ($000) $696 Avg Close $14.42 Range $12.26 - $18.07

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	126,483	$1,216	$9.58	$8.67 - $10.75
Q3 2025	36,883	$347	$9.55	$7.87 - $11.84
Q2 2025	19,083	$202	$12.62	$10.47 - $15.45
Q1 2025	20,783	$312	$16.64	$14.79 - $18.37
Q4 2024	26,283	$433	$19.72	$15.83 - $25.65
Q3 2024	39,083	$965	$25.93	$24.15 - $29.12
Q2 2024	52,383	$1,327	$25.92	$23.92 - $28.67
Q1 2024	71,583	$1,818	$24.20	$21.00 - $27.31
Q4 2023	62,283	$1,411	$20.69	$17.88 - $24.25
Q3 2023	45,483	$847	$20.74	$16.54 - $26.32
Q2 2023	70,683	$1,836	$26.76	$24.49 - $29.26
Q1 2023	73,483	$2,110	$29.76	$23.02 - $32.33
Q4 2022	86,283	$2,554	$28.44	$23.19 - $32.51
Q3 2022	69,283	$1,649	$23.01	$21.44 - $25.21
Q2 2022	84,883	$1,895	$22.31	$19.95 - $25.67
Q1 2022	68,683	$1,725	$30.49	$24.21 - $36.85
Q4 2021	59,583	$2,135	$40.03	$35.65 - $45.81
Q3 2021	63,783	$2,715	$41.19	$38.52 - $44.87
Q2 2021	107,783	$4,666	$42.59	$38.88 - $48.37
Q1 2021	106,783	$4,356	$37.93	$32.30 - $47.15
Q4 2020	82,783	$3,747	$37.95	$32.04 - $47.48
Q3 2020	88,683	$3,138	$36.12	$32.21 - $39.70
Q2 2020	92,193	$3,478	$32.95	$27.38 - $38.17
Q1 2020	91,719	$2,652	$40.45	$22.01 - $55.10
Q4 2019	115,619	$5,995	$58.09	$51.37 - $75.72
Q3 2019	159,019	$8,729	$51.34	$39.45 - $58.93
Q2 2019	202,419	$8,222	$36.46	$29.98 - $41.88
Q1 2019	217,119	$6,566	$34.25	$29.01 - $40.71
Q4 2018	125,419	$4,215	$36.09	$29.58 - $43.45
Q3 2018	129,019	$5,442	$39.51	$31.91 - $44.95
Q2 2018	143,519	$4,593	$41.18	$28.54 - $49.75
Q1 2018	65,119	$3,238	$56.50	$45.74 - $69.81
Q4 2017	65,519	$3,532	$55.35	$51.10 - $60.29
Q3 2017	81,119	$4,705	$52.27	$45.09 - $59.28
Q2 2017	91,719	$4,525	$46.05	$42.51 - $49.99
Q1 2017	71,519	$3,107	$47.74	$41.64 - $52.39
Q4 2016	66,111	$3,237	$46.23	$41.38 - $50.19
Q3 2016	67,082	$3,210	$49.40	$45.25 - $54.96
Q2 2016	87,983	$4,720	$47.12	$42.36 - $53.68
Q1 2016	92,383	$4,131	$40.56	$35.07 - $47.24
Q4 2015	76,183	$2,907	$38.25	$30.94 - $43.82
Q3 2015	44,783	$1,432	$34.87	$30.93 - $39.24
Q4 2014	8,683	$354	$39.09	$34.16 - $43.24
Q3 2014	28,983	$1,063	$43.21	$35.39 - $50.89
Q2 2014	57,383	$2,659	$44.47	$35.62 - $51.40
Q1 2014	53,583	$2,203	$37.17	$28.79 - $52.49
Q4 2013	64,083	$2,446	$30.85	$23.26 - $38.68
Q3 2013	69,783	$1,672	$22.45	$17.02 - $27.80
Q2 2013	40,883	$696	$14.42	$12.26 - $18.07