ANNOVIS BIO INC

Ticker: ANVS CUSIP: 03615A108 Class: 0

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 551,837 Value ($000) $1,909 Avg Close $3.01 Range $1.57 - $5.50

Q1 2025

Shares 166,219 Value ($000) $249 Avg Close $3.06 Range $1.43 - $5.60

Q4 2024

Shares 10,923 Value ($000) $55 Avg Close $7.24 Range $4.21 - $10.54

Q4 2021

Shares 51,747 Value ($000) $910 Avg Close $25.77 Range $17.45 - $39.72

Q3 2021

Shares 97,566 Value ($000) $3,098 Avg Close $57.50 Range $29.30 - $132.00

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	551,837	$1,909	$3.01	$1.57 - $5.50
Q1 2025	166,219	$249	$3.06	$1.43 - $5.60
Q4 2024	10,923	$55	$7.24	$4.21 - $10.54
Q4 2021	51,747	$910	$25.77	$17.45 - $39.72
Q3 2021	97,566	$3,098	$57.50	$29.30 - $132.00