APTOSE BIOSCIENCES INC

CUSIP: 03835T200 Class: Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 43,107 Value ($000) $28 Avg Close — Range —
Q4 2022
Shares 59,265 Value ($000) $34 Avg Close — Range —
Q3 2022
Shares 86,520 Value ($000) $51 Avg Close — Range —
Q2 2022
Shares 74,632 Value ($000) $55 Avg Close — Range —
Q1 2022
Shares 438,888 Value ($000) $597 Avg Close — Range —
Q4 2021
Shares 688,849 Value ($000) $930 Avg Close — Range —
Q3 2021
Shares 218,633 Value ($000) $477 Avg Close — Range —
Q2 2020
Shares 55,877 Value ($000) $353 Avg Close — Range —
Q4 2019
Shares 83,482 Value ($000) $473 Avg Close — Range —