APTOSE BIOSCIENCES INC

CUSIP: 03835T200 Class: Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 70,450 Value ($000) $45 Avg Close — Range —
Q4 2022
Shares 113,800 Value ($000) $66 Avg Close — Range —
Q3 2022
Shares 137,500 Value ($000) $82 Avg Close — Range —
Q2 2022
Shares 176,000 Value ($000) $131 Avg Close — Range —
Q1 2022
Shares 351,900 Value ($000) $479 Avg Close — Range —
Q4 2021
Shares 279,900 Value ($000) $378 Avg Close — Range —
Q3 2021
Shares 106,400 Value ($000) $232 Avg Close — Range —
Q2 2021
Shares 144,600 Value ($000) $480 Avg Close — Range —
Q1 2021
Shares 213,300 Value ($000) $1,274 Avg Close — Range —
Q4 2020
Shares 263,000 Value ($000) $1,152 Avg Close — Range —
Q3 2020
Shares 292,081 Value ($000) $1,752 Avg Close — Range —
Q2 2020
Shares 308,081 Value ($000) $1,944 Avg Close — Range —
Q1 2020
Shares 299,700 Value ($000) $1,780 Avg Close — Range —
Q4 2019
Shares 301,400 Value ($000) $1,709 Avg Close — Range —
Q3 2019
Shares 94,700 Value ($000) $197 Avg Close — Range —
Q2 2019
Shares 45,300 Value ($000) $118 Avg Close — Range —
Q1 2019
Shares 19,500 Value ($000) $39 Avg Close — Range —
Q4 2018
Shares 19,800 Value ($000) $38 Avg Close — Range —
Q3 2018
Shares 19,800 Value ($000) $51 Avg Close — Range —
Q2 2018
Shares 19,800 Value ($000) $78 Avg Close — Range —