APTINYX INC

CUSIP: 03836N103 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 81,232 Value ($000) $10 Avg Close — Range —
Q4 2022
Shares 174,225 Value ($000) $50 Avg Close — Range —
Q3 2022
Shares 184,525 Value ($000) $68 Avg Close — Range —
Q2 2022
Shares 227,487 Value ($000) $127 Avg Close — Range —
Q1 2022
Shares 38,066 Value ($000) $86 Avg Close — Range —
Q4 2021
Shares 46,102 Value ($000) $123 Avg Close — Range —
Q3 2021
Shares 21,900 Value ($000) $51 Avg Close — Range —
Q2 2021
Shares 53,100 Value ($000) $150 Avg Close — Range —
Q1 2021
Shares 670,111 Value ($000) $2,010 Avg Close — Range —
Q4 2020
Shares 432,635 Value ($000) $1,497 Avg Close — Range —
Q3 2020
Shares 142,848 Value ($000) $483 Avg Close — Range —
Q2 2020
Shares 93,118 Value ($000) $388 Avg Close — Range —
Q1 2020
Shares 111,975 Value ($000) $242 Avg Close — Range —
Q4 2019
Shares 120,382 Value ($000) $412 Avg Close — Range —
Q3 2019
Shares 166,576 Value ($000) $581 Avg Close — Range —
Q2 2019
Shares 206,728 Value ($000) $690 Avg Close — Range —
Q1 2019
Shares 114,911 Value ($000) $465 Avg Close — Range —