APTINYX INC

CUSIP: 03836N103 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 15,000 Value ($000) $2 Avg Close — Range —
Q4 2022
Shares 212,900 Value ($000) $61 Avg Close — Range —
Q3 2022
Shares 222,200 Value ($000) $82 Avg Close — Range —
Q2 2022
Shares 233,400 Value ($000) $130 Avg Close — Range —
Q1 2022
Shares 167,100 Value ($000) $379 Avg Close — Range —
Q4 2021
Shares 200,800 Value ($000) $536 Avg Close — Range —
Q3 2021
Shares 247,500 Value ($000) $579 Avg Close — Range —
Q2 2021
Shares 388,800 Value ($000) $1,100 Avg Close — Range —
Q1 2021
Shares 623,800 Value ($000) $1,871 Avg Close — Range —
Q4 2020
Shares 473,600 Value ($000) $1,639 Avg Close — Range —
Q3 2020
Shares 171,500 Value ($000) $580 Avg Close — Range —
Q2 2020
Shares 105,800 Value ($000) $441 Avg Close — Range —
Q1 2020
Shares 100,800 Value ($000) $218 Avg Close — Range —
Q4 2019
Shares 82,600 Value ($000) $282 Avg Close — Range —
Q3 2019
Shares 92,600 Value ($000) $323 Avg Close — Range —
Q2 2019
Shares 82,100 Value ($000) $274 Avg Close — Range —