ARQULE INC

CUSIP: 04269E107 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2019
Shares 243,106 Value ($000) $4,852 Avg Close — Range —
Q3 2019
Shares 486,679 Value ($000) $3,489 Avg Close — Range —
Q2 2019
Shares 103,174 Value ($000) $1,136 Avg Close — Range —
Q1 2019
Shares 159,272 Value ($000) $763 Avg Close — Range —
Q4 2018
Shares 451,901 Value ($000) $1,252 Avg Close — Range —
Q3 2018
Shares 137,410 Value ($000) $778 Avg Close — Range —
Q1 2018
Shares 93,141 Value ($000) $268 Avg Close — Range —
Q3 2015
Shares 19,518 Value ($000) $36 Avg Close — Range —
Q2 2015
Shares 102,479 Value ($000) $164 Avg Close — Range —
Q1 2015
Shares 204,997 Value ($000) $459 Avg Close — Range —
Q4 2014
Shares 151,418 Value ($000) $185 Avg Close — Range —
Q3 2014
Shares 195,200 Value ($000) $219 Avg Close — Range —
Q2 2014
Shares 396,305 Value ($000) $614 Avg Close — Range —
Q1 2014
Shares 11,638 Value ($000) $24 Avg Close — Range —
Q4 2013
Shares 44,863 Value ($000) $96 Avg Close — Range —
Q2 2013
Shares 65,417 Value ($000) $152 Avg Close — Range —