ARQULE INC

CUSIP: 04269E107 Class: Common Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 10,692 Value ($000) $30 Avg Close — Range —
Q3 2017
Shares 34,672 Value ($000) $38 Avg Close — Range —