ARSANIS INC

CUSIP: 042873109 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2018
Shares 21,496 Value ($000) $50 Avg Close — Range —
Q3 2018
Shares 35,557 Value ($000) $58 Avg Close — Range —