AVALANCHE BIOTECHNOLOGIES IN

CUSIP: 05337G107 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 14,800 Value ($000) $74 Avg Close — Range —
Q4 2015
Shares 13,750 Value ($000) $131 Avg Close — Range —
Q3 2015
Shares 13,165 Value ($000) $109 Avg Close — Range —
Q2 2015
Shares 12,774 Value ($000) $207 Avg Close — Range —
Q1 2015
Shares 5,605 Value ($000) $227 Avg Close — Range —
Q4 2014
Shares 4,932 Value ($000) $266 Avg Close — Range —