AVALANCHE BIOTECHNOLOGIES IN

CUSIP: 05337G107 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 29,500 Value ($000) $153 Avg Close — Range —
Q4 2015
Shares 14,900 Value ($000) $142 Avg Close — Range —
Q3 2015
Shares 18,300 Value ($000) $158 Avg Close — Range —