AYTU BIOPHARMA INC

Ticker: AYTU CUSIP: 054754858 Class: COMMON STOCK

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 42,500 Value ($000) $111 Avg Close $2.24 Range $1.80 - $2.67

Q3 2025

Shares 39,800 Value ($000) $75 Avg Close $2.31 Range $1.65 - $2.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	42,500	$111	$2.24	$1.80 - $2.67
Q3 2025	39,800	$75	$2.31	$1.65 - $2.82