BIOGEN INC

Ticker: BIIB CUSIP: 09062X103 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 8,800 Value ($000) $1,549 Avg Close $163.37 Range $138.00 - $185.17

Q3 2025

Shares 13,500 Value ($000) $1,891 Avg Close $135.17 Range $121.05 - $150.28

Q2 2025

Shares 455,500 Value ($000) $57,206 Avg Close $124.60 Range $110.04 - $137.32

Q1 2025

Shares 677,400 Value ($000) $92,695 Avg Close $142.96 Range $128.51 - $157.09

Q4 2024

Shares 534,600 Value ($000) $81,751 Avg Close $168.67 Range $145.07 - $195.00

Q3 2024

Shares 427,600 Value ($000) $82,886 Avg Close $209.21 Range $188.78 - $238.00

Q2 2024

Shares 192,500 Value ($000) $44,625 Avg Close $217.32 Range $189.44 - $237.54

Q1 2024

Shares 171,300 Value ($000) $36,937 Avg Close $234.20 Range $211.02 - $268.30

Q4 2023

Shares 41,100 Value ($000) $10,635 Avg Close $245.62 Range $220.86 - $269.43

Q3 2023

Shares 52,900 Value ($000) $13,596 Avg Close $267.47 Range $251.85 - $287.60

Q2 2023

Shares 157,200 Value ($000) $44,778 Avg Close $297.86 Range $273.39 - $319.76

Q1 2023

Shares 301,200 Value ($000) $83,743 Avg Close $276.70 Range $254.80 - $295.90

Q4 2022

Shares 804,300 Value ($000) $222,727 Avg Close $282.44 Range $250.31 - $311.88

Q3 2022

Shares 876,300 Value ($000) $233,972 Avg Close $212.38 Range $193.65 - $283.44

Q2 2022

Shares 995,600 Value ($000) $203,043 Avg Close $204.43 Range $187.16 - $225.50

Q1 2022

Shares 1,098,100 Value ($000) $231,260 Avg Close $217.46 Range $192.67 - $249.00

Q4 2021

Shares 455,200 Value ($000) $109,212 Avg Close $257.12 Range $221.72 - $290.76

Q3 2021

Shares 50,700 Value ($000) $14,348 Avg Close $327.75 Range $282.64 - $372.12

Q3 2020

Shares 9,700 Value ($000) $2,752 Avg Close $278.91 Range $261.87 - $312.00

Q2 2020

Shares 55,900 Value ($000) $14,956 Avg Close $300.59 Range $257.60 - $350.24

Q1 2020

Shares 88,000 Value ($000) $27,841 Avg Close $303.47 Range $262.25 - $374.99

Q4 2019

Shares 203,100 Value ($000) $60,266 Avg Close $277.46 Range $219.70 - $318.00

Q3 2019

Shares 601,600 Value ($000) $140,065 Avg Close $232.85 Range $215.78 - $246.99

Q2 2019

Shares 572,600 Value ($000) $133,914 Avg Close $230.90 Range $219.20 - $245.35

Q1 2019

Shares 67,800 Value ($000) $16,027 Avg Close $314.89 Range $216.12 - $344.00

Q4 2018

Shares 164,800 Value ($000) $49,592 Avg Close $319.14 Range $278.46 - $358.41

Q3 2018

Shares 34,800 Value ($000) $12,295 Avg Close $344.30 Range $288.13 - $388.67

Q2 2018

Shares 11,100 Value ($000) $3,222 Avg Close $281.15 Range $249.17 - $310.91

Q1 2018

Shares 1,000 Value ($000) $274 Avg Close $310.41 Range $259.76 - $370.57

Q1 2017

Shares 1,200 Value ($000) $328 Avg Close $282.75 Range $260.50 - $301.42

Q4 2016

Shares 445,810 Value ($000) $126,423 Avg Close $296.43 Range $268.00 - $329.83

Q2 2016

Shares 397,169 Value ($000) $96,043 Avg Close $263.54 Range $223.02 - $292.69

Q1 2016

Shares 256,969 Value ($000) $66,894 Avg Close $264.15 Range $242.07 - $301.02

Q4 2015

Shares 482,677 Value ($000) $147,868 Avg Close $287.35 Range $254.00 - $311.65

Q3 2015

Shares 286,596 Value ($000) $83,635 Avg Close $330.23 Range $265.00 - $412.24

Q2 2015

Shares 176,267 Value ($000) $71,201 Avg Close $401.33 Range $368.88 - $432.88

Q4 2014

Shares 168,669 Value ($000) $57,255 Avg Close $323.51 Range $290.85 - $361.93

Q3 2014

Shares 159,069 Value ($000) $52,622 Avg Close $329.72 Range $298.31 - $349.00

Q4 2013

Shares 25,669 Value ($000) $7,181 Avg Close $258.65 Range $221.07 - $298.82

Q3 2013

Shares 76,669 Value ($000) $18,460 Avg Close $223.81 Range $203.55 - $248.95

Q2 2013

Shares 21,569 Value ($000) $4,643 Avg Close $213.68 Range $191.80 - $242.64

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	8,800	$1,549	$163.37	$138.00 - $185.17
Q3 2025	13,500	$1,891	$135.17	$121.05 - $150.28
Q2 2025	455,500	$57,206	$124.60	$110.04 - $137.32
Q1 2025	677,400	$92,695	$142.96	$128.51 - $157.09
Q4 2024	534,600	$81,751	$168.67	$145.07 - $195.00
Q3 2024	427,600	$82,886	$209.21	$188.78 - $238.00
Q2 2024	192,500	$44,625	$217.32	$189.44 - $237.54
Q1 2024	171,300	$36,937	$234.20	$211.02 - $268.30
Q4 2023	41,100	$10,635	$245.62	$220.86 - $269.43
Q3 2023	52,900	$13,596	$267.47	$251.85 - $287.60
Q2 2023	157,200	$44,778	$297.86	$273.39 - $319.76
Q1 2023	301,200	$83,743	$276.70	$254.80 - $295.90
Q4 2022	804,300	$222,727	$282.44	$250.31 - $311.88
Q3 2022	876,300	$233,972	$212.38	$193.65 - $283.44
Q2 2022	995,600	$203,043	$204.43	$187.16 - $225.50
Q1 2022	1,098,100	$231,260	$217.46	$192.67 - $249.00
Q4 2021	455,200	$109,212	$257.12	$221.72 - $290.76
Q3 2021	50,700	$14,348	$327.75	$282.64 - $372.12
Q3 2020	9,700	$2,752	$278.91	$261.87 - $312.00
Q2 2020	55,900	$14,956	$300.59	$257.60 - $350.24
Q1 2020	88,000	$27,841	$303.47	$262.25 - $374.99
Q4 2019	203,100	$60,266	$277.46	$219.70 - $318.00
Q3 2019	601,600	$140,065	$232.85	$215.78 - $246.99
Q2 2019	572,600	$133,914	$230.90	$219.20 - $245.35
Q1 2019	67,800	$16,027	$314.89	$216.12 - $344.00
Q4 2018	164,800	$49,592	$319.14	$278.46 - $358.41
Q3 2018	34,800	$12,295	$344.30	$288.13 - $388.67
Q2 2018	11,100	$3,222	$281.15	$249.17 - $310.91
Q1 2018	1,000	$274	$310.41	$259.76 - $370.57
Q1 2017	1,200	$328	$282.75	$260.50 - $301.42
Q4 2016	445,810	$126,423	$296.43	$268.00 - $329.83
Q2 2016	397,169	$96,043	$263.54	$223.02 - $292.69
Q1 2016	256,969	$66,894	$264.15	$242.07 - $301.02
Q4 2015	482,677	$147,868	$287.35	$254.00 - $311.65
Q3 2015	286,596	$83,635	$330.23	$265.00 - $412.24
Q2 2015	176,267	$71,201	$401.33	$368.88 - $432.88
Q4 2014	168,669	$57,255	$323.51	$290.85 - $361.93
Q3 2014	159,069	$52,622	$329.72	$298.31 - $349.00
Q4 2013	25,669	$7,181	$258.65	$221.07 - $298.82
Q3 2013	76,669	$18,460	$223.81	$203.55 - $248.95
Q2 2013	21,569	$4,643	$213.68	$191.80 - $242.64