BIO-TECHNE CORP

Ticker: TECH CUSIP: 09073M104 Class: EQTY

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 60,300 Value ($000) $3,546 Avg Close $60.72 Range $54.13 - $66.87

Q3 2025

Shares 60,300 Value ($000) $3,354 Avg Close $53.45 Range $47.52 - $59.89

Q2 2025

Shares 42,400 Value ($000) $2,181 Avg Close $50.06 Range $45.80 - $58.49

Q1 2025

Shares 26,300 Value ($000) $1,542 Avg Close $67.42 Range $56.35 - $78.83

Q4 2024

Shares 38,500 Value ($000) $2,773 Avg Close $72.98 Range $65.24 - $80.26

Q3 2024

Shares 35,600 Value ($000) $2,846 Avg Close $74.60 Range $69.60 - $82.97

Q2 2024

Shares 35,504 Value ($000) $2,544 Avg Close $72.99 Range $60.62 - $84.91

Q3 2023

Shares 143,259 Value ($000) $9,752 Avg Close $78.07 Range $65.84 - $88.81

Q2 2023

Shares 47,658 Value ($000) $3,890 Avg Close $79.36 Range $71.21 - $86.05

Q1 2023

Shares 363,765 Value ($000) $26,988 Avg Close $76.02 Range $68.89 - $87.58

Q4 2022

Shares 43,306 Value ($000) $3,589 Avg Close $78.25 Range $66.97 - $89.34

Q3 2022

Shares 64,318 Value ($000) $18,266 Avg Close $85.06 Range $69.28 - $97.74

Q2 2022

Shares 22,702 Value ($000) $7,869 Avg Close $92.17 Range $78.24 - $111.87

Q4 2021

Shares 8,510 Value ($000) $4,403 Avg Close $120.38 Range $110.44 - $130.51

Q3 2021

Shares 4,900 Value ($000) $2,374 Avg Close $119.43 Range $107.71 - $133.47

Q3 2020

Shares 7,110 Value ($000) $1,761 Avg Close $63.60 Range $55.93 - $70.03

Q2 2020

Shares 4,647 Value ($000) $1,227 Avg Close $58.49 Range $43.96 - $69.01

Q2 2019

Shares 6,000 Value ($000) $1,251 Avg Close $48.91 Range $43.73 - $52.56

Q4 2018

Shares 15,664 Value ($000) $2,267 Avg Close $40.40 Range $32.13 - $49.71

Q3 2017

Shares 7,135 Value ($000) $863 Avg Close $28.39 Range $26.83 - $29.70

Q2 2017

Shares 21,610 Value ($000) $2,539 Avg Close $26.08 Range $23.39 - $28.66

Q3 2016

Shares 78,070 Value ($000) $8,549 Avg Close $25.95 Range $24.60 - $27.71

Q2 2016

Shares 28,599 Value ($000) $3,225 Avg Close $24.23 Range $21.51 - $27.04

Q1 2016

Shares 11,919 Value ($000) $1,127 Avg Close $20.69 Range $18.73 - $22.78

Q4 2014

Shares 22,263 Value ($000) $2,057 Avg Close $21.13 Range $19.82 - $22.17

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	60,300	$3,546	$60.72	$54.13 - $66.87
Q3 2025	60,300	$3,354	$53.45	$47.52 - $59.89
Q2 2025	42,400	$2,181	$50.06	$45.80 - $58.49
Q1 2025	26,300	$1,542	$67.42	$56.35 - $78.83
Q4 2024	38,500	$2,773	$72.98	$65.24 - $80.26
Q3 2024	35,600	$2,846	$74.60	$69.60 - $82.97
Q2 2024	35,504	$2,544	$72.99	$60.62 - $84.91
Q3 2023	143,259	$9,752	$78.07	$65.84 - $88.81
Q2 2023	47,658	$3,890	$79.36	$71.21 - $86.05
Q1 2023	363,765	$26,988	$76.02	$68.89 - $87.58
Q4 2022	43,306	$3,589	$78.25	$66.97 - $89.34
Q3 2022	64,318	$18,266	$85.06	$69.28 - $97.74
Q2 2022	22,702	$7,869	$92.17	$78.24 - $111.87
Q4 2021	8,510	$4,403	$120.38	$110.44 - $130.51
Q3 2021	4,900	$2,374	$119.43	$107.71 - $133.47
Q3 2020	7,110	$1,761	$63.60	$55.93 - $70.03
Q2 2020	4,647	$1,227	$58.49	$43.96 - $69.01
Q2 2019	6,000	$1,251	$48.91	$43.73 - $52.56
Q4 2018	15,664	$2,267	$40.40	$32.13 - $49.71
Q3 2017	7,135	$863	$28.39	$26.83 - $29.70
Q2 2017	21,610	$2,539	$26.08	$23.39 - $28.66
Q3 2016	78,070	$8,549	$25.95	$24.60 - $27.71
Q2 2016	28,599	$3,225	$24.23	$21.51 - $27.04
Q1 2016	11,919	$1,127	$20.69	$18.73 - $22.78
Q4 2014	22,263	$2,057	$21.13	$19.82 - $22.17