BIOFRONTERA INC

CUSIP: 09077D100 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022
Shares 16,200 Value ($000) $30 Avg Close — Range —
Q1 2022
Shares 36,000 Value ($000) $120 Avg Close — Range —
Q4 2021
Shares 18,600 Value ($000) $140 Avg Close — Range —