BLUEPRINT MEDICINES CORP

CUSIP: 09627Y109 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 12,800 Value ($000) $576 Avg Close — Range —
Q4 2022
Shares 45,709 Value ($000) $2,003 Avg Close — Range —
Q3 2022
Shares 109,235 Value ($000) $7,197 Avg Close — Range —
Q2 2022
Shares 10,713 Value ($000) $541 Avg Close — Range —
Q4 2019
Shares 43,318 Value ($000) $3,470 Avg Close — Range —
Q3 2019
Shares 118,370 Value ($000) $8,697 Avg Close — Range —
Q2 2019
Shares 216,526 Value ($000) $20,425 Avg Close — Range —
Q1 2019
Shares 98,213 Value ($000) $7,862 Avg Close — Range —
Q4 2018
Shares 209,866 Value ($000) $11,314 Avg Close — Range —
Q3 2018
Shares 113,859 Value ($000) $8,888 Avg Close — Range —
Q1 2018
Shares 75,488 Value ($000) $6,922 Avg Close — Range —
Q4 2017
Shares 50,210 Value ($000) $3,786 Avg Close — Range —
Q3 2017
Shares 110,693 Value ($000) $7,712 Avg Close — Range —
Q2 2017
Shares 63,477 Value ($000) $3,216 Avg Close — Range —
Q1 2017
Shares 148,105 Value ($000) $5,923 Avg Close — Range —
Q3 2016
Shares 9,700 Value ($000) $288 Avg Close — Range —