BLUEPRINT MEDICINES CORP

CUSIP: 09627Y109 Class: Common Stock

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 56,442 Value ($000) $1,019 Avg Close — Range —
Q4 2015
Shares 878,348 Value ($000) $23,136 Avg Close — Range —
Q3 2015
Shares 878,348 Value ($000) $18,744 Avg Close — Range —
Q2 2015
Shares 878,348 Value ($000) $23,267 Avg Close — Range —