BLUEPRINT MEDICINES CORP

CUSIP: 09627Y109 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 47,200 Value ($000) $2,124 Avg Close — Range —
Q4 2022
Shares 75,900 Value ($000) $3,325 Avg Close — Range —
Q3 2022
Shares 61,900 Value ($000) $4,079 Avg Close — Range —
Q4 2019
Shares 73,600 Value ($000) $5,896 Avg Close — Range —
Q3 2019
Shares 117,100 Value ($000) $8,603 Avg Close — Range —
Q2 2019
Shares 114,200 Value ($000) $10,772 Avg Close — Range —
Q1 2019
Shares 116,400 Value ($000) $9,318 Avg Close — Range —
Q4 2018
Shares 159,300 Value ($000) $8,588 Avg Close — Range —
Q3 2018
Shares 161,600 Value ($000) $12,614 Avg Close — Range —
Q2 2018
Shares 227,000 Value ($000) $14,410 Avg Close — Range —
Q1 2018
Shares 75,200 Value ($000) $6,896 Avg Close — Range —
Q4 2017
Shares 81,400 Value ($000) $6,138 Avg Close — Range —
Q3 2017
Shares 43,000 Value ($000) $2,996 Avg Close — Range —
Q2 2017
Shares 9,900 Value ($000) $502 Avg Close — Range —
Q1 2017
Shares 11,400 Value ($000) $456 Avg Close — Range —