BRICKELL BIOTECH INC

CUSIP: 10802T105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021
Shares 105,785 Value ($000) $24 Avg Close — Range —
Q3 2021
Shares 90,085 Value ($000) $65 Avg Close — Range —
Q2 2021
Shares 23,885 Value ($000) $23 Avg Close — Range —
Q1 2021
Shares 73,285 Value ($000) $80 Avg Close — Range —