BRICKELL BIOTECH INC

CUSIP: 10802T105 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021
Shares 422,500 Value ($000) $97 Avg Close — Range —
Q3 2021
Shares 245,900 Value ($000) $177 Avg Close — Range —
Q2 2021
Shares 158,800 Value ($000) $151 Avg Close — Range —
Q1 2021
Shares 98,800 Value ($000) $108 Avg Close — Range —