TVARDI THERAPEUTICS INC

Ticker: TVRD CUSIP: 140755307 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 10,492 Value ($000) $45 Avg Close $8.96 Range $3.74 - $43.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	10,492	$45	$8.96	$3.74 - $43.65