CARDIOME PHARMA CORP

CUSIP: 14159U301 Class: COM NO PAR

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016
Shares 627,363 Value ($000) $1,970 Avg Close — Range —
Q2 2016
Shares 627,363 Value ($000) $3,218 Avg Close — Range —
Q1 2016
Shares 627,363 Value ($000) $2,566 Avg Close — Range —
Q4 2015
Shares 627,363 Value ($000) $5,088 Avg Close — Range —
Q3 2015
Shares 816,582 Value ($000) $6,892 Avg Close — Range —
Q2 2015
Shares 816,582 Value ($000) $7,684 Avg Close — Range —
Q1 2015
Shares 894,761 Value ($000) $8,285 Avg Close — Range —
Q4 2014
Shares 1,103,771 Value ($000) $10,210 Avg Close — Range —
Q3 2014
Shares 1,188,871 Value ($000) $10,617 Avg Close — Range —
Q2 2014
Shares 1,678,323 Value ($000) $13,212 Avg Close — Range —
Q1 2014
Shares 1,516,012 Value ($000) $12,000 Avg Close — Range —
Q4 2013
Shares 306,412 Value ($000) $1,933 Avg Close — Range —
Q3 2013
Shares 175,112 Value ($000) $623 Avg Close — Range —
Q2 2013
Shares 152,912 Value ($000) $297 Avg Close — Range —