CARDIOME PHARMA CORP

CUSIP: 14159U301 Class: COM NO PAR

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 500,000 Value ($000) $4,220 Avg Close — Range —
Q2 2015
Shares 500,000 Value ($000) $4,705 Avg Close — Range —
Q1 2015
Shares 500,000 Value ($000) $4,645 Avg Close — Range —
Q4 2014
Shares 600,000 Value ($000) $5,524 Avg Close — Range —
Q3 2014
Shares 950,000 Value ($000) $8,469 Avg Close — Range —
Q2 2014
Shares 1,132,260 Value ($000) $8,917 Avg Close — Range —
Q1 2014
Shares 1,132,260 Value ($000) $8,968 Avg Close — Range —
Q4 2013
Shares 1,332,260 Value ($000) $8,386 Avg Close — Range —
Q3 2013
Shares 1,332,260 Value ($000) $4,733 Avg Close — Range —
Q2 2013
Shares 1,332,260 Value ($000) $2,598 Avg Close — Range —