CARDIOME PHARMA CORP

CUSIP: 14159U301 Class: COM NO PAR

CLOUGH CAPITAL PARTNERS L P's Holding History (CIK: 0001276144)

Note: Option positions (PUT/CALL) are excluded.

Q1 2018
Shares 2,075,663 Value ($000) $4,816 Avg Close — Range —
Q4 2017
Shares 2,667,585 Value ($000) $4,135 Avg Close — Range —
Q3 2017
Shares 2,878,985 Value ($000) $6,132 Avg Close — Range —
Q2 2017
Shares 2,878,985 Value ($000) $13,013 Avg Close — Range —
Q1 2017
Shares 2,958,415 Value ($000) $8,905 Avg Close — Range —
Q4 2016
Shares 3,061,064 Value ($000) $8,449 Avg Close — Range —
Q3 2016
Shares 3,061,064 Value ($000) $9,581 Avg Close — Range —
Q2 2016
Shares 2,061,064 Value ($000) $10,553 Avg Close — Range —
Q1 2016
Shares 2,044,653 Value ($000) $8,363 Avg Close — Range —
Q4 2015
Shares 1,738,353 Value ($000) $14,098 Avg Close — Range —
Q3 2015
Shares 1,584,083 Value ($000) $13,370 Avg Close — Range —
Q2 2015
Shares 787,583 Value ($000) $7,411 Avg Close — Range —
Q1 2015
Shares 597,183 Value ($000) $5,530 Avg Close — Range —
Q4 2014
Shares 512,533 Value ($000) $4,741 Avg Close — Range —
Q3 2014
Shares 499,004 Value ($000) $4,456 Avg Close — Range —
Q2 2014
Shares 360,721 Value ($000) $2,832 Avg Close — Range —