CASTLE BIOSCIENCES INC

Ticker: CSTL CUSIP: 14843C105 Class: Common Stock

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 29,899 Value ($000) $1,163 Avg Close $32.24 Range $22.05 - $42.17

Q3 2025

Shares 9,900 Value ($000) $225 Avg Close $20.31 Range $14.59 - $24.74

Q2 2025

Shares 12,000 Value ($000) $245 Avg Close $18.51 Range $15.45 - $22.82

Q1 2025

Shares 69,200 Value ($000) $1,385 Avg Close $24.76 Range $18.70 - $32.74

Q4 2024

Shares 11,500 Value ($000) $306 Avg Close $30.46 Range $25.82 - $35.84

Q1 2024

Shares 19,000 Value ($000) $421 Avg Close $21.76 Range $17.42 - $25.60

Q4 2023

Shares 32,100 Value ($000) $693 Avg Close $17.60 Range $12.07 - $22.66

Q3 2023

Shares 56,500 Value ($000) $954 Avg Close $17.49 Range $13.18 - $20.96

Q2 2023

Shares 93,000 Value ($000) $1,276 Avg Close $20.26 Range $9.26 - $26.70

Q1 2023

Shares 112,300 Value ($000) $2,551 Avg Close $24.43 Range $18.79 - $29.59

Q4 2022

Shares 132,100 Value ($000) $3,110 Avg Close $23.18 Range $17.82 - $30.08

Q3 2022

Shares 153,400 Value ($000) $4,001 Avg Close $28.03 Range $21.78 - $36.09

Q2 2022

Shares 155,300 Value ($000) $3,409 Avg Close $23.24 Range $15.58 - $47.27

Q1 2022

Shares 23,800 Value ($000) $1,068 Avg Close $41.32 Range $31.46 - $48.40

Q4 2021

Shares 111,500 Value ($000) $4,780 Avg Close $52.25 Range $37.99 - $68.65

Q3 2021

Shares 79,800 Value ($000) $5,307 Avg Close $70.37 Range $57.64 - $78.58

Q2 2021

Shares 50,800 Value ($000) $3,725 Avg Close $66.05 Range $48.01 - $78.92

Q1 2021

Shares 62,100 Value ($000) $4,251 Avg Close $75.16 Range $56.74 - $107.69

Q4 2020

Shares 25,100 Value ($000) $1,685 Avg Close $54.21 Range $43.37 - $78.39

Q3 2020

Shares 11,800 Value ($000) $607 Avg Close $44.49 Range $36.15 - $52.41

Q2 2020

Shares 14,300 Value ($000) $539 Avg Close $34.17 Range $25.07 - $44.53

Q1 2020

Shares 13,500 Value ($000) $402 Avg Close $30.17 Range $21.01 - $36.39

Q4 2019

Shares 14,400 Value ($000) $495 Avg Close $24.45 Range $15.26 - $39.77

Q3 2019

Shares 16,400 Value ($000) $297 Avg Close $22.17 Range $17.10 - $28.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	29,899	$1,163	$32.24	$22.05 - $42.17
Q3 2025	9,900	$225	$20.31	$14.59 - $24.74
Q2 2025	12,000	$245	$18.51	$15.45 - $22.82
Q1 2025	69,200	$1,385	$24.76	$18.70 - $32.74
Q4 2024	11,500	$306	$30.46	$25.82 - $35.84
Q1 2024	19,000	$421	$21.76	$17.42 - $25.60
Q4 2023	32,100	$693	$17.60	$12.07 - $22.66
Q3 2023	56,500	$954	$17.49	$13.18 - $20.96
Q2 2023	93,000	$1,276	$20.26	$9.26 - $26.70
Q1 2023	112,300	$2,551	$24.43	$18.79 - $29.59
Q4 2022	132,100	$3,110	$23.18	$17.82 - $30.08
Q3 2022	153,400	$4,001	$28.03	$21.78 - $36.09
Q2 2022	155,300	$3,409	$23.24	$15.58 - $47.27
Q1 2022	23,800	$1,068	$41.32	$31.46 - $48.40
Q4 2021	111,500	$4,780	$52.25	$37.99 - $68.65
Q3 2021	79,800	$5,307	$70.37	$57.64 - $78.58
Q2 2021	50,800	$3,725	$66.05	$48.01 - $78.92
Q1 2021	62,100	$4,251	$75.16	$56.74 - $107.69
Q4 2020	25,100	$1,685	$54.21	$43.37 - $78.39
Q3 2020	11,800	$607	$44.49	$36.15 - $52.41
Q2 2020	14,300	$539	$34.17	$25.07 - $44.53
Q1 2020	13,500	$402	$30.17	$21.01 - $36.39
Q4 2019	14,400	$495	$24.45	$15.26 - $39.77
Q3 2019	16,400	$297	$22.17	$17.10 - $28.50