CHARLES RIV LABS INTL INC

Ticker: CRL CUSIP: 159864107 Class: EQTY

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 311,657 Value ($000) $62,169 Avg Close $181.39 Range $156.06 - $205.00

Q3 2025

Shares 134,535 Value ($000) $21,049 Avg Close $158.82 Range $144.26 - $184.17

Q2 2025

Shares 45,000 Value ($000) $6,828 Avg Close $133.35 Range $91.86 - $154.43

Q2 2024

Shares 42,269 Value ($000) $8,732 Avg Close $226.59 Range $203.60 - $273.32

Q1 2024

Shares 87,183 Value ($000) $23,622 Avg Close $238.81 Range $201.01 - $275.00

Q4 2023

Shares 154,055 Value ($000) $36,419 Avg Close $196.66 Range $161.65 - $239.84

Q3 2023

Shares 109,713 Value ($000) $21,502 Avg Close $205.30 Range $191.10 - $218.83

Q2 2023

Shares 11,148 Value ($000) $2,344 Avg Close $198.96 Range $181.22 - $212.91

Q1 2023

Shares 7,805 Value ($000) $1,575 Avg Close $226.63 Range $188.85 - $262.00

Q4 2022

Shares 51,800 Value ($000) $11,287 Avg Close $218.37 Range $189.76 - $252.40

Q2 2022

Shares 52,900 Value ($000) $11,319 Avg Close $244.35 Range $203.37 - $308.15

Q1 2022

Shares 12,700 Value ($000) $3,606 Avg Close $308.36 Range $251.30 - $376.78

Q4 2021

Shares 53,800 Value ($000) $20,271 Avg Close $388.52 Range $347.74 - $449.34

Q3 2021

Shares 54,600 Value ($000) $22,532 Avg Close $415.31 Range $368.43 - $460.21

Q2 2021

Shares 55,400 Value ($000) $20,494 Avg Close $333.92 Range $290.31 - $372.51

Q4 2017

Shares 150,000 Value ($000) $16,418 Avg Close $108.82 Range $99.12 - $119.05

Q3 2017

Shares 100,000 Value ($000) $10,802 Avg Close $102.74 Range $94.15 - $109.59

Q4 2015

Shares 39,500 Value ($000) $3,175 Avg Close $72.12 Range $59.99 - $81.61

Q2 2015

Shares 200,000 Value ($000) $14,068 Avg Close $74.00 Range $68.59 - $79.44

Q1 2014

Shares 614,268 Value ($000) $37,065 Avg Close $58.29 Range $52.41 - $62.50

Q4 2013

Shares 504,268 Value ($000) $26,746 Avg Close $50.22 Range $44.12 - $53.81

Q3 2013

Shares 454,268 Value ($000) $21,014 Avg Close $45.89 Range $41.05 - $48.73

Q2 2013

Shares 504,268 Value ($000) $20,690 Avg Close $42.84 Range $40.28 - $45.90

Q1 2013

Shares 504,268 Value ($000) $22,324 Avg Close $41.89 Range $37.38 - $46.90

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	311,657	$62,169	$181.39	$156.06 - $205.00
Q3 2025	134,535	$21,049	$158.82	$144.26 - $184.17
Q2 2025	45,000	$6,828	$133.35	$91.86 - $154.43
Q2 2024	42,269	$8,732	$226.59	$203.60 - $273.32
Q1 2024	87,183	$23,622	$238.81	$201.01 - $275.00
Q4 2023	154,055	$36,419	$196.66	$161.65 - $239.84
Q3 2023	109,713	$21,502	$205.30	$191.10 - $218.83
Q2 2023	11,148	$2,344	$198.96	$181.22 - $212.91
Q1 2023	7,805	$1,575	$226.63	$188.85 - $262.00
Q4 2022	51,800	$11,287	$218.37	$189.76 - $252.40
Q2 2022	52,900	$11,319	$244.35	$203.37 - $308.15
Q1 2022	12,700	$3,606	$308.36	$251.30 - $376.78
Q4 2021	53,800	$20,271	$388.52	$347.74 - $449.34
Q3 2021	54,600	$22,532	$415.31	$368.43 - $460.21
Q2 2021	55,400	$20,494	$333.92	$290.31 - $372.51
Q4 2017	150,000	$16,418	$108.82	$99.12 - $119.05
Q3 2017	100,000	$10,802	$102.74	$94.15 - $109.59
Q4 2015	39,500	$3,175	$72.12	$59.99 - $81.61
Q2 2015	200,000	$14,068	$74.00	$68.59 - $79.44
Q1 2014	614,268	$37,065	$58.29	$52.41 - $62.50
Q4 2013	504,268	$26,746	$50.22	$44.12 - $53.81
Q3 2013	454,268	$21,014	$45.89	$41.05 - $48.73
Q2 2013	504,268	$20,690	$42.84	$40.28 - $45.90
Q1 2013	504,268	$22,324	$41.89	$37.38 - $46.90