CYNAPSUS THERAPEUTICS INC

CUSIP: 23257Y859 Class: COM PAR NO PAR

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 650,000 Value ($000) $10,888 Avg Close — Range —
Q1 2016
Shares 650,000 Value ($000) $7,735 Avg Close — Range —
Q4 2015
Shares 650,000 Value ($000) $9,939 Avg Close — Range —
Q3 2015
Shares 650,000 Value ($000) $10,511 Avg Close — Range —
Q2 2015
Shares 600,000 Value ($000) $9,774 Avg Close — Range —