DIAMEDICA THERAPEUTICS INC

Ticker: DMAC CUSIP: 25253X207 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022

Shares 12,149 Value ($000) $19 Avg Close $1.35 Range $1.12 - $1.80

Q3 2022

Shares 14,518 Value ($000) $18 Avg Close $1.56 Range $1.15 - $2.10

Q2 2022

Shares 17,249 Value ($000) $35 Avg Close $2.33 Range $1.62 - $2.71

Q1 2022

Shares 50,068 Value ($000) $125 Avg Close $2.84 Range $2.20 - $3.94

Q4 2021

Shares 140,857 Value ($000) $525 Avg Close $3.93 Range $3.28 - $4.80

Q3 2021

Shares 74,280 Value ($000) $298 Avg Close $3.83 Range $3.00 - $4.82

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2022	12,149	$19	$1.35	$1.12 - $1.80
Q3 2022	14,518	$18	$1.56	$1.15 - $2.10
Q2 2022	17,249	$35	$2.33	$1.62 - $2.71
Q1 2022	50,068	$125	$2.84	$2.20 - $3.94
Q4 2021	140,857	$525	$3.93	$3.28 - $4.80
Q3 2021	74,280	$298	$3.83	$3.00 - $4.82