DIFFUSION PHARMACEUTICALS IN

CUSIP: 253748305 Class: COM PAR

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2020
Shares 106,341 Value ($000) $85 Avg Close — Range —
Q4 2018
Shares 32,176 Value ($000) $64 Avg Close — Range —