DIFFUSION PHARMACEUTICALS IN

CUSIP: 253748305 Class: COM PAR

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 165,000 Value ($000) $41 Avg Close — Range —
Q4 2021
Shares 224,000 Value ($000) $68 Avg Close — Range —
Q1 2021
Shares 48,700 Value ($000) $45 Avg Close — Range —
Q4 2020
Shares 69,700 Value ($000) $55 Avg Close — Range —
Q1 2020
Shares 12,900 Value ($000) $4 Avg Close — Range —