DURECT CORP

CUSIP: 266605500 Class: COM NEW

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q2 2023
Shares 22,199 Value ($000) $110 Avg Close — Range —
Q1 2023
Shares 29,569 Value ($000) $134 Avg Close — Range —
Q4 2022
Shares 41,069 Value ($000) $142 Avg Close — Range —