EPIRUS BIOPHARMACEUTICALS IN

CUSIP: 29428P107 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 772,007 Value ($000) $349 Avg Close — Range —
Q1 2016
Shares 772,007 Value ($000) $2,077 Avg Close — Range —
Q4 2015
Shares 772,007 Value ($000) $2,386 Avg Close — Range —
Q3 2015
Shares 522,007 Value ($000) $2,307 Avg Close — Range —
Q2 2015
Shares 522,007 Value ($000) $2,981 Avg Close — Range —
Q1 2015
Shares 522,007 Value ($000) $4,672 Avg Close — Range —
Q4 2014
Shares 522,007 Value ($000) $2,960 Avg Close — Range —
Q3 2014
Shares 522,007 Value ($000) $3,753 Avg Close — Range —