ESPERION THERAPEUTICS INC NE

Ticker: ESPR CUSIP: 29664W105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,742,082 Value ($000) $17,546 Avg Close $3.23 Range $2.30 - $4.13

Q3 2025

Shares 2,238,618 Value ($000) $5,932 Avg Close $1.93 Range $0.95 - $2.94

Q2 2025

Shares 1,827,994 Value ($000) $1,799 Avg Close $1.00 Range $0.69 - $1.46

Q1 2025

Shares 2,731,287 Value ($000) $3,933 Avg Close $1.84 Range $1.42 - $2.40

Q4 2024

Shares 3,540,361 Value ($000) $7,789 Avg Close $2.33 Range $1.58 - $3.94

Q3 2024

Shares 3,625,059 Value ($000) $5,981 Avg Close $2.02 Range $1.60 - $2.77

Q2 2024

Shares 4,074,961 Value ($000) $9,046 Avg Close $2.35 Range $1.71 - $3.40

Q1 2024

Shares 3,975,560 Value ($000) $10,655 Avg Close $2.43 Range $1.65 - $3.34

Q4 2023

Shares 2,334,410 Value ($000) $6,980 Avg Close $1.30 Range $0.70 - $3.28

Q3 2023

Shares 1,457,935 Value ($000) $1,429 Avg Close $1.45 Range $0.85 - $1.99

Q2 2023

Shares 1,176,848 Value ($000) $1,636 Avg Close $1.40 Range $1.12 - $1.84

Q1 2023

Shares 1,062,898 Value ($000) $1,690 Avg Close $5.16 Range $1.26 - $7.41

Q4 2022

Shares 1,537,664 Value ($000) $9,580 Avg Close $7.15 Range $4.88 - $8.87

Q3 2022

Shares 1,068,438 Value ($000) $7,159 Avg Close $6.87 Range $5.29 - $8.48

Q2 2022

Shares 382,403 Value ($000) $2,432 Avg Close $5.67 Range $4.59 - $7.05

Q1 2022

Shares 139,899 Value ($000) $649 Avg Close $4.29 Range $3.28 - $5.66

Q4 2021

Shares 342,647 Value ($000) $1,713 Avg Close $8.01 Range $4.70 - $12.15

Q1 2021

Shares 48,670 Value ($000) $1,365 Avg Close $29.50 Range $24.73 - $39.49

Q4 2020

Shares 51,964 Value ($000) $1,351 Avg Close $29.96 Range $23.90 - $37.97

Q3 2020

Shares 18,930 Value ($000) $704 Avg Close $39.61 Range $30.54 - $53.73

Q2 2020

Shares 28,132 Value ($000) $1,443 Avg Close $41.84 Range $29.11 - $53.00

Q3 2019

Shares 39,484 Value ($000) $1,447 Avg Close $39.61 Range $33.13 - $47.94

Q2 2019

Shares 144,774 Value ($000) $6,735 Avg Close $46.96 Range $39.03 - $52.99

Q1 2019

Shares 24,522 Value ($000) $985 Avg Close $44.86 Range $39.29 - $54.94

Q2 2017

Shares 69,877 Value ($000) $3,234 Avg Close $36.77 Range $30.95 - $49.69

Q1 2017

Shares 90,118 Value ($000) $3,182 Avg Close $22.90 Range $10.71 - $48.21

Q2 2015

Shares 273,502 Value ($000) $22,362 Avg Close $97.89 Range $72.05 - $120.96

Q1 2015

Shares 138,983 Value ($000) $12,870 Avg Close $64.53 Range $41.00 - $118.95

Q4 2014

Shares 38,250 Value ($000) $1,547 Avg Close $30.61 Range $18.00 - $42.24

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,742,082	$17,546	$3.23	$2.30 - $4.13
Q3 2025	2,238,618	$5,932	$1.93	$0.95 - $2.94
Q2 2025	1,827,994	$1,799	$1.00	$0.69 - $1.46
Q1 2025	2,731,287	$3,933	$1.84	$1.42 - $2.40
Q4 2024	3,540,361	$7,789	$2.33	$1.58 - $3.94
Q3 2024	3,625,059	$5,981	$2.02	$1.60 - $2.77
Q2 2024	4,074,961	$9,046	$2.35	$1.71 - $3.40
Q1 2024	3,975,560	$10,655	$2.43	$1.65 - $3.34
Q4 2023	2,334,410	$6,980	$1.30	$0.70 - $3.28
Q3 2023	1,457,935	$1,429	$1.45	$0.85 - $1.99
Q2 2023	1,176,848	$1,636	$1.40	$1.12 - $1.84
Q1 2023	1,062,898	$1,690	$5.16	$1.26 - $7.41
Q4 2022	1,537,664	$9,580	$7.15	$4.88 - $8.87
Q3 2022	1,068,438	$7,159	$6.87	$5.29 - $8.48
Q2 2022	382,403	$2,432	$5.67	$4.59 - $7.05
Q1 2022	139,899	$649	$4.29	$3.28 - $5.66
Q4 2021	342,647	$1,713	$8.01	$4.70 - $12.15
Q1 2021	48,670	$1,365	$29.50	$24.73 - $39.49
Q4 2020	51,964	$1,351	$29.96	$23.90 - $37.97
Q3 2020	18,930	$704	$39.61	$30.54 - $53.73
Q2 2020	28,132	$1,443	$41.84	$29.11 - $53.00
Q3 2019	39,484	$1,447	$39.61	$33.13 - $47.94
Q2 2019	144,774	$6,735	$46.96	$39.03 - $52.99
Q1 2019	24,522	$985	$44.86	$39.29 - $54.94
Q2 2017	69,877	$3,234	$36.77	$30.95 - $49.69
Q1 2017	90,118	$3,182	$22.90	$10.71 - $48.21
Q2 2015	273,502	$22,362	$97.89	$72.05 - $120.96
Q1 2015	138,983	$12,870	$64.53	$41.00 - $118.95
Q4 2014	38,250	$1,547	$30.61	$18.00 - $42.24