GLOBAL BLOOD THERAPEUTICS IN

CUSIP: 37890U108 Class: COMMON STOCK

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 314,839 Value ($000) $21,441 Avg Close — Range —
Q2 2022
Shares 170,798 Value ($000) $5,457 Avg Close — Range —
Q1 2022
Shares 438,080 Value ($000) $15,175 Avg Close — Range —
Q4 2021
Shares 191,505 Value ($000) $5,605 Avg Close — Range —
Q4 2019
Shares 171,922 Value ($000) $13,666 Avg Close — Range —