HERON THERAPEUTICS INC

Ticker: HRTX CUSIP: 427746102 Class: COM

GREAT LAKES ADVISORS, LLC's Holding History (CIK: 0001078013)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022

Shares 15,380 Value ($000) $88 Avg Close $7.32 Range $4.58 - $10.40

Q4 2021

Shares 15,380 Value ($000) $140 Avg Close $10.21 Range $8.23 - $12.79

Q3 2021

Shares 793,156 Value ($000) $8,479 Avg Close $12.17 Range $10.10 - $16.16

Q2 2021

Shares 722,978 Value ($000) $11,221 Avg Close $15.91 Range $12.96 - $18.99

Q4 2019

Shares 259,247 Value ($000) $6,092 Avg Close $22.12 Range $17.25 - $26.81

Q3 2019

Shares 258,201 Value ($000) $4,777 Avg Close $18.41 Range $15.68 - $21.80

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2022	15,380	$88	$7.32	$4.58 - $10.40
Q4 2021	15,380	$140	$10.21	$8.23 - $12.79
Q3 2021	793,156	$8,479	$12.17	$10.10 - $16.16
Q2 2021	722,978	$11,221	$15.91	$12.96 - $18.99
Q4 2019	259,247	$6,092	$22.12	$17.25 - $26.81
Q3 2019	258,201	$4,777	$18.41	$15.68 - $21.80