HERON THERAPEUTICS INC

Ticker: HRTX CUSIP: 427746102 Class: COM

Itau Unibanco Holding S.A.'s Holding History (CIK: 0001132597)

Note: Option positions (PUT/CALL) are excluded.

Q3 2019

Shares 423 Value ($000) $8 Avg Close $18.41 Range $15.68 - $21.80

Q2 2019

Shares 423 Value ($000) $8 Avg Close $19.98 Range $16.20 - $26.59

Q1 2019

Shares 760 Value ($000) $18 Avg Close $26.18 Range $22.87 - $28.70

Q4 2018

Shares 760 Value ($000) $18 Avg Close $27.49 Range $21.25 - $32.45

Q3 2018

Shares 693 Value ($000) $22 Avg Close $37.25 Range $29.30 - $41.55

Q2 2018

Shares 313 Value ($000) $12 Avg Close $31.84 Range $26.00 - $42.90

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2019	423	$8	$18.41	$15.68 - $21.80
Q2 2019	423	$8	$19.98	$16.20 - $26.59
Q1 2019	760	$18	$26.18	$22.87 - $28.70
Q4 2018	760	$18	$27.49	$21.25 - $32.45
Q3 2018	693	$22	$37.25	$29.30 - $41.55
Q2 2018	313	$12	$31.84	$26.00 - $42.90