HERON THERAPEUTICS INC

Ticker: HRTX CUSIP: 427746102 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 12,136 Value ($000) $16 Avg Close $1.23 Range $1.00 - $1.44

Q2 2025

Shares 14,376 Value ($000) $30 Avg Close $2.04 Range $1.65 - $2.61

Q2 2022

Shares 10,685 Value ($000) $30 Avg Close $4.02 Range $2.19 - $6.38

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	12,136	$16	$1.23	$1.00 - $1.44
Q2 2025	14,376	$30	$2.04	$1.65 - $2.61
Q2 2022	10,685	$30	$4.02	$2.19 - $6.38