IMMUNE DESIGN CORP

CUSIP: 45252L103 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 196,624 Value ($000) $1,150 Avg Close — Range —
Q4 2018
Shares 415,254 Value ($000) $540 Avg Close — Range —
Q3 2018
Shares 140,919 Value ($000) $486 Avg Close — Range —
Q1 2018
Shares 131,010 Value ($000) $432 Avg Close — Range —
Q4 2017
Shares 217,917 Value ($000) $850 Avg Close — Range —
Q3 2017
Shares 16,476 Value ($000) $171 Avg Close — Range —