2020 144A

CUSIP: 45337CAL6 Class: CONV BONDS

BAKER BROS. ADVISORS LP's Holding History (CIK: 0001263508)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016

Shares 274,500,000 Value ($000) $558,650 Avg Close — Range —

Q3 2016

Shares 274,500,000 Value ($000) $531,244 Avg Close — Range —

Q2 2016

Shares 274,500,000 Value ($000) $467,293 Avg Close — Range —

Q1 2016

Shares 274,500,000 Value ($000) $432,150 Avg Close — Range —

Q4 2015

Shares 274,500,000 Value ($000) $596,530 Avg Close — Range —

Q3 2015

Shares 274,500,000 Value ($000) $598,696 Avg Close — Range —

Q2 2015

Shares 274,500,000 Value ($000) $567,758 Avg Close — Range —

Q1 2015

Shares 274,500,000 Value ($000) $508,427 Avg Close — Range —

Q4 2014

Shares 274,500,000 Value ($000) $421,613 Avg Close — Range —

Q3 2014

Shares 274,500,000 Value ($000) $334,033 Avg Close — Range —

Q2 2014

Shares 274,500,000 Value ($000) $371,605 Avg Close — Range —

Q1 2014

Shares 274,500,000 Value ($000) $350,417 Avg Close — Range —

Q4 2013

Shares 274,500,000 Value ($000) $333,004 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2016	274,500,000	$558,650	—	—
Q3 2016	274,500,000	$531,244	—	—
Q2 2016	274,500,000	$467,293	—	—
Q1 2016	274,500,000	$432,150	—	—
Q4 2015	274,500,000	$596,530	—	—
Q3 2015	274,500,000	$598,696	—	—
Q2 2015	274,500,000	$567,758	—	—
Q1 2015	274,500,000	$508,427	—	—
Q4 2014	274,500,000	$421,613	—	—
Q3 2014	274,500,000	$334,033	—	—
Q2 2014	274,500,000	$371,605	—	—
Q1 2014	274,500,000	$350,417	—	—
Q4 2013	274,500,000	$333,004	—	—