IONIS PHARMACEUTICALS INC

CUSIP: 462222AD2 Class: NOTE 4/0

Federation des caisses Desjardins du Quebec's Holding History (CIK: 0002022297)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022
Shares 280,000 Value ($000) $260 Avg Close — Range —
Q3 2022
Shares 280,000 Value ($000) $280 Avg Close — Range —
Q2 2022
Shares 280,000 Value ($000) $255 Avg Close — Range —