IOVANCE BIOTHERAPEUTICS INC

Ticker: IOVA CUSIP: 462260100 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 231,443 Value ($000) $637 Avg Close $2.31 Range $1.76 - $2.99

Q3 2025

Shares 225,215 Value ($000) $489 Avg Close $2.36 Range $1.67 - $4.33

Q2 2025

Shares 273,986 Value ($000) $471 Avg Close $2.49 Range $1.64 - $3.73

Q1 2025

Shares 271,826 Value ($000) $905 Avg Close $5.16 Range $3.19 - $8.15

Q4 2024

Shares 279,627 Value ($000) $2,069 Avg Close $9.27 Range $7.05 - $12.51

Q3 2024

Shares 311,907 Value ($000) $2,929 Avg Close $9.47 Range $7.11 - $12.50

Q2 2024

Shares 335,513 Value ($000) $2,691 Avg Close $10.72 Range $7.59 - $14.77

Q1 2024

Shares 358,988 Value ($000) $5,320 Avg Close $11.64 Range $7.34 - $18.33

Q4 2023

Shares 264,971 Value ($000) $2,154 Avg Close $5.23 Range $3.21 - $9.03

Q3 2023

Shares 263,929 Value ($000) $1,201 Avg Close $6.53 Range $4.36 - $8.82

Q2 2023

Shares 220,852 Value ($000) $1,555 Avg Close $7.16 Range $5.28 - $9.36

Q1 2023

Shares 164,687 Value ($000) $1,006 Avg Close $6.90 Range $5.39 - $8.49

Q4 2022

Shares 163,247 Value ($000) $1,031 Avg Close $7.81 Range $5.42 - $10.41

Q3 2022

Shares 159,821 Value ($000) $1,526 Avg Close $11.53 Range $9.46 - $13.44

Q2 2022

Shares 161,200 Value ($000) $1,764 Avg Close $13.10 Range $6.18 - $18.73

Q1 2022

Shares 103,303 Value ($000) $1,725 Avg Close $15.46 Range $12.18 - $19.66

Q1 2020

Shares 71,140 Value ($000) $2,130 Avg Close $26.51 Range $18.70 - $38.92

Q4 2019

Shares 65,705 Value ($000) $1,819 Avg Close $22.75 Range $17.78 - $29.68

Q3 2019

Shares 67,863 Value ($000) $1,221 Avg Close $22.11 Range $17.67 - $26.59

Q2 2019

Shares 68,138 Value ($000) $1,671 Avg Close $15.06 Range $9.52 - $25.50

Q1 2019

Shares 66,621 Value ($000) $633 Avg Close $9.71 Range $8.26 - $11.36

Q4 2018

Shares 58,566 Value ($000) $518 Avg Close $9.64 Range $7.26 - $12.30

Q3 2018

Shares 52,126 Value ($000) $586 Avg Close $14.19 Range $11.20 - $18.25

Q2 2018

Shares 59,109 Value ($000) $757 Avg Close $14.62 Range $12.20 - $17.20

Q1 2018

Shares 52,660 Value ($000) $890 Avg Close $15.14 Range $7.85 - $19.90

Q4 2017

Shares 45,817 Value ($000) $367 Avg Close $8.03 Range $6.60 - $9.54

Q3 2017

Shares 40,707 Value ($000) $316 Avg Close $6.33 Range $4.45 - $8.60

Q2 2017

Shares 41,835 Value ($000) $308 Avg Close $6.36 Range $4.90 - $7.50

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	231,443	$637	$2.31	$1.76 - $2.99
Q3 2025	225,215	$489	$2.36	$1.67 - $4.33
Q2 2025	273,986	$471	$2.49	$1.64 - $3.73
Q1 2025	271,826	$905	$5.16	$3.19 - $8.15
Q4 2024	279,627	$2,069	$9.27	$7.05 - $12.51
Q3 2024	311,907	$2,929	$9.47	$7.11 - $12.50
Q2 2024	335,513	$2,691	$10.72	$7.59 - $14.77
Q1 2024	358,988	$5,320	$11.64	$7.34 - $18.33
Q4 2023	264,971	$2,154	$5.23	$3.21 - $9.03
Q3 2023	263,929	$1,201	$6.53	$4.36 - $8.82
Q2 2023	220,852	$1,555	$7.16	$5.28 - $9.36
Q1 2023	164,687	$1,006	$6.90	$5.39 - $8.49
Q4 2022	163,247	$1,031	$7.81	$5.42 - $10.41
Q3 2022	159,821	$1,526	$11.53	$9.46 - $13.44
Q2 2022	161,200	$1,764	$13.10	$6.18 - $18.73
Q1 2022	103,303	$1,725	$15.46	$12.18 - $19.66
Q1 2020	71,140	$2,130	$26.51	$18.70 - $38.92
Q4 2019	65,705	$1,819	$22.75	$17.78 - $29.68
Q3 2019	67,863	$1,221	$22.11	$17.67 - $26.59
Q2 2019	68,138	$1,671	$15.06	$9.52 - $25.50
Q1 2019	66,621	$633	$9.71	$8.26 - $11.36
Q4 2018	58,566	$518	$9.64	$7.26 - $12.30
Q3 2018	52,126	$586	$14.19	$11.20 - $18.25
Q2 2018	59,109	$757	$14.62	$12.20 - $17.20
Q1 2018	52,660	$890	$15.14	$7.85 - $19.90
Q4 2017	45,817	$367	$8.03	$6.60 - $9.54
Q3 2017	40,707	$316	$6.33	$4.45 - $8.60
Q2 2017	41,835	$308	$6.36	$4.90 - $7.50