IOVANCE BIOTHERAPEUTICS INC

Ticker: IOVA CUSIP: 462260100 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 4,397,989 Value ($000) $12,007 Avg Close $2.31 Range $1.76 - $2.99

Q3 2025

Shares 2,740,854 Value ($000) $5,948 Avg Close $2.36 Range $1.67 - $4.33

Q2 2025

Shares 4,633,451 Value ($000) $7,970 Avg Close $2.49 Range $1.64 - $3.73

Q1 2025

Shares 396,994 Value ($000) $1,322 Avg Close $5.16 Range $3.19 - $8.15

Q3 2024

Shares 92,368 Value ($000) $867 Avg Close $9.47 Range $7.11 - $12.50

Q2 2024

Shares 774,783 Value ($000) $6,214 Avg Close $10.72 Range $7.59 - $14.77

Q3 2023

Shares 227,000 Value ($000) $1,033 Avg Close $6.53 Range $4.36 - $8.82

Q2 2023

Shares 1,531,053 Value ($000) $10,779 Avg Close $7.16 Range $5.28 - $9.36

Q1 2023

Shares 2,557,187 Value ($000) $15,624 Avg Close $6.90 Range $5.39 - $8.49

Q4 2022

Shares 893,933 Value ($000) $5,712 Avg Close $7.81 Range $5.42 - $10.41

Q3 2022

Shares 1,411,158 Value ($000) $13,519 Avg Close $11.53 Range $9.46 - $13.44

Q2 2022

Shares 533,600 Value ($000) $5,891 Avg Close $13.10 Range $6.18 - $18.73

Q1 2022

Shares 124,900 Value ($000) $2,080 Avg Close $15.46 Range $12.18 - $19.66

Q4 2021

Shares 381,881 Value ($000) $7,290 Avg Close $22.02 Range $15.94 - $27.96

Q3 2021

Shares 258,930 Value ($000) $6,385 Avg Close $23.56 Range $20.19 - $27.01

Q1 2021

Shares 170,300 Value ($000) $5,392 Avg Close $41.45 Range $27.75 - $54.21

Q4 2020

Shares 307,162 Value ($000) $14,252 Avg Close $39.70 Range $24.67 - $52.43

Q3 2020

Shares 10,736 Value ($000) $353 Avg Close $30.66 Range $26.75 - $36.93

Q2 2020

Shares 88,609 Value ($000) $2,432 Avg Close $32.88 Range $26.34 - $41.49

Q4 2019

Shares 189,327 Value ($000) $5,241 Avg Close $22.75 Range $17.78 - $29.68

Q3 2019

Shares 501,770 Value ($000) $9,132 Avg Close $22.11 Range $17.67 - $26.59

Q1 2019

Shares 149,841 Value ($000) $1,425 Avg Close $9.71 Range $8.26 - $11.36

Q4 2018

Shares 351,532 Value ($000) $3,111 Avg Close $9.64 Range $7.26 - $12.30

Q2 2018

Shares 263,475 Value ($000) $3,372 Avg Close $14.62 Range $12.20 - $17.20

Q1 2018

Shares 14,400 Value ($000) $243 Avg Close $15.14 Range $7.85 - $19.90

Q4 2017

Shares 28,294 Value ($000) $226 Avg Close $8.03 Range $6.60 - $9.54

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	4,397,989	$12,007	$2.31	$1.76 - $2.99
Q3 2025	2,740,854	$5,948	$2.36	$1.67 - $4.33
Q2 2025	4,633,451	$7,970	$2.49	$1.64 - $3.73
Q1 2025	396,994	$1,322	$5.16	$3.19 - $8.15
Q3 2024	92,368	$867	$9.47	$7.11 - $12.50
Q2 2024	774,783	$6,214	$10.72	$7.59 - $14.77
Q3 2023	227,000	$1,033	$6.53	$4.36 - $8.82
Q2 2023	1,531,053	$10,779	$7.16	$5.28 - $9.36
Q1 2023	2,557,187	$15,624	$6.90	$5.39 - $8.49
Q4 2022	893,933	$5,712	$7.81	$5.42 - $10.41
Q3 2022	1,411,158	$13,519	$11.53	$9.46 - $13.44
Q2 2022	533,600	$5,891	$13.10	$6.18 - $18.73
Q1 2022	124,900	$2,080	$15.46	$12.18 - $19.66
Q4 2021	381,881	$7,290	$22.02	$15.94 - $27.96
Q3 2021	258,930	$6,385	$23.56	$20.19 - $27.01
Q1 2021	170,300	$5,392	$41.45	$27.75 - $54.21
Q4 2020	307,162	$14,252	$39.70	$24.67 - $52.43
Q3 2020	10,736	$353	$30.66	$26.75 - $36.93
Q2 2020	88,609	$2,432	$32.88	$26.34 - $41.49
Q4 2019	189,327	$5,241	$22.75	$17.78 - $29.68
Q3 2019	501,770	$9,132	$22.11	$17.67 - $26.59
Q1 2019	149,841	$1,425	$9.71	$8.26 - $11.36
Q4 2018	351,532	$3,111	$9.64	$7.26 - $12.30
Q2 2018	263,475	$3,372	$14.62	$12.20 - $17.20
Q1 2018	14,400	$243	$15.14	$7.85 - $19.90
Q4 2017	28,294	$226	$8.03	$6.60 - $9.54