ISHARES TR

Ticker: RXI CUSIP: 464288745 Class: GLB CNS DISC ETF

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022

Shares 3,910 Value ($000) $497 Avg Close — Range —

Q4 2019

Shares 2,059 Value ($000) $259 Avg Close — Range —

Q4 2018

Shares 2,133 Value ($000) $215 Avg Close — Range —

Q3 2018

Shares 1,921 Value ($000) $231 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q2 2022	3,910	$497	—	—
Q4 2019	2,059	$259	—	—
Q4 2018	2,133	$215	—	—
Q3 2018	1,921	$231	—	—