ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

FRED ALGER MANAGEMENT, LLC's Holding History (CIK: 0000003520)

Note: Option positions (PUT/CALL) are excluded.

Q1 2015
Shares 161,972 Value ($000) $10,313 Avg Close — Range —
Q4 2014
Shares 287,079 Value ($000) $17,724 Avg Close — Range —
Q3 2014
Shares 144,037 Value ($000) $5,593 Avg Close — Range —
Q2 2014
Shares 174,450 Value ($000) $6,010 Avg Close — Range —
Q1 2014
Shares 330,855 Value ($000) $14,296 Avg Close — Range —
Q4 2013
Shares 282,460 Value ($000) $11,253 Avg Close — Range —