ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

US BANCORP \DE\'s Holding History (CIK: 0000036104)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 4,793 Value ($000) $194 Avg Close — Range —
Q2 2015
Shares 4,174 Value ($000) $240 Avg Close — Range —
Q1 2015
Shares 5,628 Value ($000) $358 Avg Close — Range —
Q4 2014
Shares 6,305 Value ($000) $390 Avg Close — Range —
Q3 2014
Shares 8,649 Value ($000) $336 Avg Close — Range —
Q2 2014
Shares 12,584 Value ($000) $433 Avg Close — Range —
Q1 2014
Shares 40,215 Value ($000) $1,738 Avg Close — Range —
Q4 2013
Shares 10,325 Value ($000) $411 Avg Close — Range —
Q3 2013
Shares 8,515 Value ($000) $320 Avg Close — Range —
Q2 2013
Shares 3,117 Value ($000) $84 Avg Close — Range —