ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

M&T Bank Corp's Holding History (CIK: 0000036270)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 13,251 Value ($000) $536 Avg Close — Range —
Q2 2015
Shares 23,395 Value ($000) $1,347 Avg Close — Range —
Q1 2015
Shares 30,308 Value ($000) $1,929 Avg Close — Range —
Q4 2014
Shares 15,500 Value ($000) $957 Avg Close — Range —
Q3 2014
Shares 18,826 Value ($000) $731 Avg Close — Range —
Q1 2014
Shares 21 Value ($000) $1 Avg Close — Range —