ISIS PHARMACEUTICALS INC

CUSIP: 464330109 Class: CMN

CENTRAL TRUST Co's Holding History (CIK: 0000044365)

Note: Option positions (PUT/CALL) are excluded.

Q3 2015
Shares 200 Value ($000) $8 Avg Close — Range —
Q2 2015
Shares 200 Value ($000) $12 Avg Close — Range —